TABLE 1.

Reported cases of multidrug-resistant A. baumannii CNS infections treated with colistin

Characteristic	Data from reference no.:
	11	8	9	13	2	4	6	6	10
No. of patients	5	1	1	1	1	2	1	1	1
Age (yr)/sex	NRa	55/F	14/Male	41/F	49/F	NR	16/Male	34/F	28/Male
Underlying condition	NR	MEN	CT	SH	MEN	NR	HEM	SH	CT
CNS infection	M, V	M	M	M	M	NR	V	V	M
Ventricular tubeb	NR	Yes (20)	Yes (42)	Yes (8)	NR	NR	Yes (16)	Yes (7)	NR
MIC (μg/ml)	NR	1	0.3	0.5	NR	NR	≤4	≤4	NR
Colistin methanesulfonate dosage, in mg/kg of body wt/day (route)	2.5-5 (i.v.)	5 (i.v.)	5 (i.v.)	5-10 (ith)e	3.2 (ith)e	4 (i.v.) + 20 (ith)e	5-10 mg/12 h (iventr)	5-10 mg/12 h (iventr)	80 mg/8 h (i.v.) + 1.6-3.2 mg/d (iventr)
Duration of colistin treatment, in days	NR	15	30	22	17	NR	19	17	63
Antibiotic(s) coadministeredc	No	No	No	No	SAM + VAN (i.v.)	NR	SAM (3 days) + TOB (19 days) (i.v.)	TOB (17 days) (i.v.)	AMK + TEC (63 days) (i.v. + iventr)
CSF sterilizationd (days)	NR	4	5	1	6	NR	2	6	NR
Levels of colistin	No	Yes	Yes	Titers	No	No	Titers	Titers	No
Infection outcome	4 of 5 Cured	Cured	Cured	Cured	Cured	Cured	Cured	Cured	Cured

^aNR, not reported; MEN, meningioma; CT, cranial trauma; SH, subarachnoid hemorrhage; HEM, hemangioblastoma; M, meningitis; V, ventriculitis; F, female; i.v., intravenous; ith, intrathecal; iventr, intraventricular.

^bIn parentheses is the number of days from catheter insertion to diagnosis of infection.

^cSAM, ampicillin-sulbactam; VAN, vancomycin; TOB, tobramycin; AMK, amikacin; TEC, teicoplanin. The numbers in parentheses are the duration of treatment.

^dTime after initiation of colistin treatment.

^eMilligrams per day.