Table 3.
Effect of Late Intervention of Omega-3 Polyunsaturated Fatty Acid Derived from Menhaden Oil, Krill Oil, or Algal Oils Enriched in EPA, DHA or EPA/DHA on Peripheral Neuropathy-Related Endpoints in Obese Sprague Dawley Rats
| Conditions | MNCV (m/sec) | SNCV (m/sec) | Thermal Nociception (sec) | IENF (Profiles/mm) | Corneal Nerve Fiber Length (mm/mm2) | Cornea Sensitivity (cm) | Cornea Sensitivity (AUC) |
|---|---|---|---|---|---|---|---|
| Control | 56.9 ± 1.8 | 39.0 ± 0.4 | 12.2 ± 0.7 | 26.0 ± 0.3 | 7.5 ± 0.3 | 5.88 ± 0.06 | 54 ± 4 |
| Obese | 53.2 ± 1.2 | 33.0 ± 1.0a | 20.3 ± 1.1a | 19.7 ± 0.2a | 3.5 ± 0.3a | 5.03 ± 0.14a | 143 ± 12a |
| Obese + MO | 54.8 ± 2.1 | 37.6 ± 0.8b | 13.5 ± 0.6b | 22.4 ± 0.3a,b | 6.2 ± 0.3b | 5.81 ± 0.07b | 52 ± 15 |
| Obese + KO | 54.4 ± 1.6 | 37.7 ± 1.0b | 14.0 ± 0.6b | 20.7 ± 0.3a | 6.4 ± 0.6b | 5.67 ± 0.08b | 103 ± 17 |
| Obese + EPA | 50.8 ± 1.5 | 36.7 ± 1.2 | 10.8 ± 0.5b | 20.5 ± 0.3a | 4.2 ± 0.5a,c | 5.61 ± 0.10b | 102 ± 12 |
| Obese + DHA | 52.6 ± 1.8 | 38.4 ± 0.5b | 14.3 ± 0.6b | 20.6 ± 0.2a | 5.2 ± 0.5b | 5.75 ± 0.06b | 110 ± 11 |
| Obese + EPA/DHA | 53.3 ± 1.6 | 38.7 ± 0.9b | 13.4 ± 0.8b | 20.6 ± 0.3a | 6.5 ± 0.3b | 5.81 ± 0.10b | 78 ± 12 |
Notes: Data are presented as the mean ± S.E.M. n = 10–14. aP < 0.05 vs control; bP < 0.05 vs Obese; cP < 0.05 vs Obese + MO, Obese + KO, Obese + DHA and Obese + EPA/DHA.
Abbreviations: IENF, intraepidermal nerve fiber; MO, menhaden oil; KO, krill oil; AO, algal oil; EPA, eicosapentaenoic acid; DHA, docosahexaenoic acid.