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. 2005 Sep;25(18):8228–8238. doi: 10.1128/MCB.25.18.8228-8238.2005

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FIG. 3. — dGcn5 loss of function induces cell cycle defects and apoptosis. The results of a confocal analysis of GFP (green) and dGcn5 or CBP (red) expression in wing disks from en-GAL4 UAS-GFP/UAS-IR[Gcn5] (A and B) or en-GAL4/UAS-GFP (A′) late-third-instar larvae are shown. BrdU incorporation experiments (C) and anti-phospho(S10)-histone H3 immunostaining (D) revealed a greater proportion of cells in S phase and at mitosis, respectively, in the dGcn5 silenced compartment from en-GAL4 UAS-IR[Gcn5] wing disks. The results of a TUNEL analysis of Gcn5^E333st/Gcn5^E333st (E), Gcn5^E333st/TM6 Tb (F), en-GAL4/UAS-IR[Gcn5] (G), and ptc-GAL4/UAS-IR[Gcn5] (H) wing disks are also shown. UAS-IR[GFP] transgenes did not induce apoptosis in control experiments (not shown).