FIG. 4.

Small maf triple-mutant MEFs are sensitive to an oxidative stress reagent. The viability of MEFs established from mafG^+/+::mafK^−/−::mafF^−/− (G2K0F0; left graph) and mafG^−/−::mafK^−/−::mafF^−/− (G0K0F0; right graph) embryos is shown. MEFs were exposed to increasing concentrations (conc.) of CDNB (0, 5, and 10 μM) with or without DEM pretreatment. Cell viability was examined as described in the text, and the viability of the 0 μM CDNB sample was set to 100%. Closed circles, open circles, closed triangles, and open triangles indicate G2K0F0 MEFs without DEM, G2K0F0 MEFs with DEM, G0K0F0 MEFs without DEM, and G0K0F0 MEFs with DEM, respectively. Error bars indicate standard deviations.