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. 2025 Jun 30;16(8):e00353-25. doi: 10.1128/mbio.00353-25

TABLE 1.

Strains used in this study

Strain Description Reference
RN4220 Restriction-deficient, methylation-proficient cloning intermediate (78)
JE2 USA300, wild type (WT) (20)
ispA::Tn ispA transposon from NE1447 backcrossed into WT JE2 This study
hepT::Tn hepT transposon from NE1920 backcrossed into WT JE2 This study
ΔhepT In-frame deletion of hepT constructed using pKOR1-ΔhepT This study
ΔhepT ispA::Tn ispA transposon from NE1447 transduced into ΔhepT This study
menE::Tn Tn917 inserted into menE backcrossed into WT JE2 (71)
ΔmenB In-frame deletion of menB constructed using pKOR1-ΔmenB This study
menC::Tn Tn917 inserted into menC backcrossed into WT JE2 (71)
qoxA::Tn qoxA transposon from NE92 backcrossed into WT JE2 This study
cydA::Tn cydA transposon from NE117 backcrossed into WT JE2 This study
ΔmenB qoxA::Tn qoxA transposon from NE92 transduced into ΔmenB This study
ΔmenB cydA::Tn cydA transposon from NE117 transduced into ΔmenB This study
crtM::Tn crtM transposon from NE2499 backcrossed into WT JE2 This study
ΔhepT crtM::Tn crtM transposon from NE2499 transduced into ΔhepT This study
ΔispA In-frame deletion of ispA constructed using pKOR1-ΔispA This study
ΔispA qoxA::Tn qoxA transposon from NE92 transduced into ΔispA This study
ΔispA cydA::Tn cydA transposon from NE117 transduced into ΔispA This study
ΔhepT qoxA::Tn qoxA transposon from NE92 transduced into ΔhepT This study
ΔhepT cydA::Tn cydA transposon from NE117 transduced into JE2 ΔhepT This study
ispA::Tn suppressor 115 Gentamicin-resistant pigmented ispA::Tn isolate that harbors the HepTA72E allele This study
ispA::Tn suppressor 144 Gentamicin-resistant pigmented ispA::Tn isolate that harbors the HepTA72E allele This study
ispA::Tn suppressor 164 Gentamicin-resistant pigmented ispA::Tn isolate that harbors the HepTA72E allele This study
ispA::Tn suppressor 165 Gentamicin-resistant nonpigmented ispA::Tn isolate that harbors the HepTA165T allele This study
JE2 pOS1 Empty pOS1 plasmid vector This study
ispA::Tn pOS1 Empty pOS1 plasmid vector This study
ispA::Tn pOS1-ispA ispA::Tn harboring a pOS1 plasmid encoding the ispA gene under the control of the Plgt promoter This study
ΔhepT pOS1 Empty pOS1 plasmid vector control This study
ΔhepT pOS1-hepT ΔhepT harboring a pOS1 plasmid encoding the hepT gene under the control of the Plgt promoter This study
ΔhepT ispA::Tn pOS1 Empty pOS1 plasmid vector control This study
ΔhepT ispA::Tn pOS1-hepT ΔhepT ispA::Tn harboring a pOS1 plasmid encoding the hepT gene under the control of the Plgt promoter This study
ΔhepT ispA::Tn pOS1-ispA ΔhepT ispA::Tn harboring a pOS1 plasmid encoding ispA under the control of the Plgt promoter This study
ΔhepT ispA::Tn pOS1-hepTA72E ΔhepT ispA::Tn harboring a pOS1 plasmid encoding the hepTA72E allele from ispA::Tn suppressor 115 under the control of the Plgt promoter This study