TNT	Total neoadjuvant therapy;
LARC	Locally advanced rectal cancer;
NOM	Non-operative management;
TME	Total mesorectal excision;
ctDNA	Circulating tumor DNA;
MRD	Minimally residual disease;
MMR	Mismatch repair;
LE	Local excision;
pCR	Pathologic complete response;
IRB	Institutional review board;
cCR	Complete clinical response;
nCR	Near complete response;
iCR	Incomplete response.