Table 1.
Characteristics of paediatric patients with malignancies or HCT who developed Staphylococcus spp. infections.
| PHO (n = 1433) | HCT (n = 292) | ||
|---|---|---|---|
| Diagnosis | Diagnosis | ||
| ALL | 532 (37.1%) | ALL | 81 (27.7%) |
| AML | 128 (8.9%) | AML | 44 (15.1%) |
| NHL | 97 (6.8%) | MDS | 23 (7.9%) |
| HD | 43 (3.0%) | NHL | 8 (2.7%) |
| MDS | 11 (0.8%) | HD | 4 (1.4%) |
| CML | 1 (0.1%) | SAA | 23 (7.9%) |
| LCH | 12 (0.8%) | PID | 17 (5.8%) |
| CNST | 160 (11.2%) | NBL | 32 (11.0%) |
| NBL | 124 (8.7%) | ES | 5 (1.7%) |
| WT | 44 (3.1%) | Other * | 55 (18.8%) |
| ES | 34 (2.4%) | ||
| OS | 13 (0.9%) | ||
| RMS | 60 (4.2%) | ||
| GCT | 41 (2.9%) | ||
| Solid tumours (2012/2013) | 63 (4.4%) | ||
| Other * | 70 (4.9%) | ||
| Age (yr/median/min–max) | 4.6 (0.01–17.9) | Age (yr/median/min–max) | 8.1 (0.2–21.0) |
| Gender | Gender | ||
| Female | 602 (42.0%) | Female | 93 (31.8%) |
| Male | 831 (58.0%) | Male | 199 (68.2%) |
n—number of included patients in the given category; PHO—paediatric haematology and oncology, HCT—haematopoietic cell transplantation, ALL—acute lymphoblastic leukaemia, AML—acute myeloblastic leukaemia, NHL, non-Hodgkin lymphoma, HD—Hodgkin disease, MDS—myelodysplastic syndrome, CML—chronic myeloid leukaemia, SAA—severe aplastic anaemia, LCH—Langerhans cell histiocytosis, PID—primary immunodeficiency, CNST—central nervous system tumour, NBL—neuroblastoma, WT—Wilms tumour, ES—Ewing sarcoma, OS—osteosarcoma, RMS—rhabdomyosarcoma, GCT—germ cell tumour. * The full list of underlying diseases grouped under the “Other” category is provided in the Supplementary Material (Table S1 for PHO patients and Table S2 for HCT patients).