Table 2.

Intermolecular Interactions Between FCGs and Target Proteins.

Proteins	Compound	Binding Energy (kcal/mol)	Binding Residues
PPARγ	FCG1	−5.4	TYR-63
	FCG2	−5.3	MET-22 ILE-37
	FCG3	−5.9	ASN-8 LEU-47 MET-22
	FCG4	−6.0	TYR-63 GLY-62 VAL-60 ASP-58 ASN-46 ARG-47
INSR	FCG1	−7.2	LEU-1002 HIS-1081 SER-1086
	FCG2	−6.7	ALA-1080 ASP-1083
	FCG3	−6.9	ASP-1083 SER-1086 ARG-1089 GLU-1096
	FCG4	−8.1	ASP-1083 LYS-1085
PI3K	FCG1	−9.9	GLN-291 LYS-298 ASP-654 HIS-658 ARG-849
	FCG2	−8.5	GLU-852 ARG-849 GLN-846 GLU-880 ASP-788 ARG-690 ARG-277
	FCG3	−9.5	LYS-298 PRO-866 GLY-868
	FCG4	−10.4	LYS-298 GLN-291 PRO-866 ARG-849 HIS-658 LEU-657 ASP-654
AKT1	FCG1	−7.6	ARG-15
	FCG2	−7.2	GLU-32 ARG-328 ASP-325 ASN-324
	FCG3	−8.6	LYS-276 ASN-279 GLU-85
	FCG4	−7.8	ARG-346 GLY-345 LEU-347 PRO-348
NF-κB1	FCG1	−7.1	ASN-219 GLN-435
	FCG2	−7.2	GLN-439 GLN-435 ASN-257 ASP-261
	FCG3	−8.6	ASP-316 ASN-394 VAL-312 ASN-352 SER-351 TRP-318 ASN-310 ASP-271
	FCG4	−8.2	LYS-299 GLN-435 LYS-431 ASN-257
RELA	FCG1	−7.9	LYS-140 GLU-182 ARG-85
	FCG2	−6.8	TYR-25
	FCG3	−7.8	LYS-122 ARG-132 ASN-42
	FCG4	−7.3	GLU-133 SER-63 ARG-85
TNF	FCG1	−8.0	GLU-110 GLY-108 GLU-107 LYS-103 PRO-102 ASP-104
	FCG2	−8.6	GLU-107 PRO-102 LYS-112
	FCG3	−9.6	GLU-116 CYS-101 PRO-100 SER-99
	FCG4	−8.2	GLU-107 GLY-108 GLY-68 LYS-112
IL6	FCG1	−7.3	ASP-160 LYS-46 ARG-104 GLN-159
	FCG2	−7.0	ASP-140 ASN-144 GLU-93
	FCG3	−6.8	ASN-144 LYS-66
	FCG4	−7.6	LYS-46 GLN-156 ARG-104
BAX	FCG1	−8.0	ASN-104 LEU-47 PRO-130
	FCG2	−6.9	LEU-47 ALA-42 GIN-28 GLU-41
	FCG3	−6.5	ASP-98 ASP-102 MET-99 GLN-52 LYS-57
	FCG4	−7.0	ALA-35 ASN-104
BCL-2	FCG1	−8.3	PRO-163 GLY-162 SER-75
	FCG2	−9.2	ASP-62 ARG-66 ARG-26 ARG-68 LYS-22
	FCG3	−9.1	TYR-67 TYR-161 ARG-66 ARG-26 ARG-68 ARG-65
	FCG4	−9.3	PRO-163 GLU-119 ARG-66 ARG-26