Table 1.

Characteristics and Clinical Course of Patients With Radiation Necrosis

Patient’s number	Age in years	Diagnosis*	Total dose [Gy]	Administration of chemotherapy during radiotherapy	Interval between radiotherapy and occurrence of radiation necrosis in months	Location of radiation necrosis in relation to the primary tumor	Symptoms	Type of surgery	Treatment with steroids	Treatment with Avastin	Recurrent tumor at further follow-up
1	58	Oligodendroglioma WHO II°	60	No	31	Local	No	GTR	No	No	No
2	32	Oligodendroglioma WHO II°	54	Yes	4	Local	No	GTR	Yes	No	No
3	54	Oligodendroglioma WHO II°	54	No	22	Local	Yes	GTR	Yes	No	Yes
4	65	Oligodendroglioma WHO II°	54	No	6	Local	No	GTR	No	No	No
5	34	Oligodendroglioma WHOII°	60	No	22.5	Distal	no	Partial resection	Yes	No	No
6	67	Oligodendroglioma WHO II°	60	Yes	4	Distal	Yes	GTR	No	No	No
7	67	Oligodendroglioma WHO III°	60	Yes	37	Distal	No	Biopsy	Yes	Yes	Yes
8	60	Oligodendroglioma WHO III°	54	Yes	9	Local	Yes	GTR	No	No	No
9	65	Oligodendroglioma WHO III°	60	No	18	Local	No	GTR	No	No	No
10	28	Oligodendroglioma WHO III°	60	Yes	21	Local	No	GTR	No	No	No
11	80	Glioblastoma WHO IV°	60	Yes	4	Local	No	GTR	No	No	No
12	82	Glioblastoma WHO IV°	60	Yes	40	Distal	No	GTR	No	No	No
13	62	Glioblastoma WHO IV°	60	Yes	4	Local	No	GTR	No	No	No
14	35	Glioblastoma WHO IV	59.4	Yes	3	Distal	No	Partial resection	Yes	Yes	No

^*According to the 2007 World Health Organization Classification of Tumors of the Central Nervous System or its later version (2016) [9, 10]. GTR = gross total resection, Gy = gray, GTV = gross tumor volume, CTV = clinical target volume, PTV = planning target volume, Dmax = maximum dose, D0.1cm3 = dose in 0.1 cm³, VMAT = volumetric intensity-modulated arc therapy, IMRT = intensity-modulated radiation therapy, N/A = not available.