Table 2.

Spearman correlation^a between log(Serum NfL) at baseline and prognostic measures of NPC1

Measurement	${\mathit{r}}_{\mathit{s}}$ (95% CI)	FDR-Adjusted P Value	Raw P Value
Age of neuro onset (n = 109)	−0.36 (−0.51, −0.18)	.0001	.0001
ASIS (n = 104)	0.58 (0.43, 0.69)	<.0001	<.0001
5-domain severity score (n = 118)	0.43 (0.27, 0.56)	<.0001	<.0001
17-domain severity score (n = 118)	0.40 (0.24, 0.54)	<.0001	<.0001
log(CSF NfL) (n = 133)b	0.68 (0.58, 0.76)	<.0001	<.0001

ASIS, annual severity increment score; CSF, cerebrospinal fluid; NfL, neurofilament light.

^aThe Pearson correlation between log(serum NfL) and log(CSF NfL) was 0.715, based on 133 pairs of measurements. However, the normality checks revealed violations of normality assumption. Therefore, the Spearman correlation coefficient is presented here.

^bIncludes all serum samples and their available corresponding CSF samples.