Figure 1.

Multimodality cardiac imaging revealing diffuse myocardial thickening and enhancement consistent with infiltrative cardiomyopathy. A. This echocardiographic image demonstrates increased left ventricular myocardial thickness in the short-axis view. The concentric hypertrophy is suggestive of an infiltrative cardiomyopathy, requiring further evaluation. B. Diffuse Myocardial Enhancement in the Left Ventricular Short Axis View (Cardiac MRI with late gadolinium enhancement (LGE) reveals diffuse subendocardial enhancement in the left ventricular myocardium. This pattern is characteristic of cardiac amyloidosis and helps distinguish it from other hypertrophic cardiomyopathies). C. Cardiac Abnormalities (Myocardial Thickening, Pericardial Effusion, and Pleural Effusion) Evident on Four-Chamber Heart Imaging (A four-chamber view of the heart obtained via echocardiography illustrates myocardial thickening, pericardial effusion, and pleural effusion. These findings are consistent with advanced cardiac amyloidosis and systemic involvement). D. Four-Chamber Heart Displaying Diffuse Myocardial Enhancement in the Left and Right Ventricles (Late gadolinium-enhanced cardiac MRI in a four-chamber view shows diffuse myocardial enhancement in both left and right ventricles. This suggests amyloid infiltration, which is a hallmark of light-chain (AL) amyloidosis).