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. 2025 Jul 15;17(7):5120–5128. doi: 10.62347/QXZB5406

Table 3.

The threshold effect of HCV-Ab and biochemical indicators on HCV infection was analyzed using a two-stage phased regression model

Variables Models Adjusted OR (95% CI) P
HCV-Ab (S/CO) Model 1 Fitting model by standard linear regression 1.30 (1.20-1.42) < .001
Model 2 Fitting model by two-piecewise linear regression
Inflection point 11.17
    < 11.17 2.04 (1.34-3.10) < .001
    ≥ 11.17 0.77 (0.59-1.01) 0.057
P for likelihood test < .001
ALT (U/L) Model 1 Fitting model by standard linear regression 1.04 (1.03-1.06) < .001
Model 2 Fitting model by two-piecewise linear regression
Inflection point 54.00
    < 54.00 1.09 (1.04-1.14) < .001
    ≥ 54.00 1.02 (1.00-1.04) 0.112
P for likelihood test 0.017
AST (U/L) Model 1 Fitting model by standard linear regression 1.05 (1.03-1.07) < .001
Model 2 Fitting model by two-piecewise linear regression
Inflection point 39.00
    < 39.00 1.16 (1.05-1.28) 0.004
    ≥ 39.00 1.02 (1.00-1.04) 0.086
P for likelihood test 0.007
mAST (U/L) Model 1 Fitting model by standard linear regression 1.06 (1.01-1.11) 0.016
Model 2 Fitting model by two-piecewise linear regression
Inflection point 7.00
    < 7.00 1.56 (1.14-2.13) 0.006
    ≥ 7.00 1.00 (0.93-1.07) 0.983
P for likelihood test 0.005
GGT (U/L) Model 1 Fitting model by standard linear regression 1.00 (1.00-1.01) 0.026
Model 2 Fitting model by two-piecewise linear regression
Inflection point 28.00
    < 28.00 1.14 (0.99-1.30) 0.071
    ≥ 28.00 1.00 (1.00-1.01) 0.290
P for likelihood test 0.017

OR, odds ratio; CI, confidence interval; HCV-Ab, hepatitis C antibody; ALT, alanine aminotransferase; AST, aspartate aminotransferase; mAST, mitochondrial aspartate aminotransferase isoenzyme; GGT, gamma-glutamyl transferase.