Table 3.
The threshold effect of HCV-Ab and biochemical indicators on HCV infection was analyzed using a two-stage phased regression model
| Variables | Models | Adjusted OR (95% CI) | P |
|---|---|---|---|
| HCV-Ab (S/CO) | Model 1 Fitting model by standard linear regression | 1.30 (1.20-1.42) | < .001 |
| Model 2 Fitting model by two-piecewise linear regression | |||
| Inflection point | 11.17 | ||
| < 11.17 | 2.04 (1.34-3.10) | < .001 | |
| ≥ 11.17 | 0.77 (0.59-1.01) | 0.057 | |
| P for likelihood test | < .001 | ||
| ALT (U/L) | Model 1 Fitting model by standard linear regression | 1.04 (1.03-1.06) | < .001 |
| Model 2 Fitting model by two-piecewise linear regression | |||
| Inflection point | 54.00 | ||
| < 54.00 | 1.09 (1.04-1.14) | < .001 | |
| ≥ 54.00 | 1.02 (1.00-1.04) | 0.112 | |
| P for likelihood test | 0.017 | ||
| AST (U/L) | Model 1 Fitting model by standard linear regression | 1.05 (1.03-1.07) | < .001 |
| Model 2 Fitting model by two-piecewise linear regression | |||
| Inflection point | 39.00 | ||
| < 39.00 | 1.16 (1.05-1.28) | 0.004 | |
| ≥ 39.00 | 1.02 (1.00-1.04) | 0.086 | |
| P for likelihood test | 0.007 | ||
| mAST (U/L) | Model 1 Fitting model by standard linear regression | 1.06 (1.01-1.11) | 0.016 |
| Model 2 Fitting model by two-piecewise linear regression | |||
| Inflection point | 7.00 | ||
| < 7.00 | 1.56 (1.14-2.13) | 0.006 | |
| ≥ 7.00 | 1.00 (0.93-1.07) | 0.983 | |
| P for likelihood test | 0.005 | ||
| GGT (U/L) | Model 1 Fitting model by standard linear regression | 1.00 (1.00-1.01) | 0.026 |
| Model 2 Fitting model by two-piecewise linear regression | |||
| Inflection point | 28.00 | ||
| < 28.00 | 1.14 (0.99-1.30) | 0.071 | |
| ≥ 28.00 | 1.00 (1.00-1.01) | 0.290 | |
| P for likelihood test | 0.017 |
OR, odds ratio; CI, confidence interval; HCV-Ab, hepatitis C antibody; ALT, alanine aminotransferase; AST, aspartate aminotransferase; mAST, mitochondrial aspartate aminotransferase isoenzyme; GGT, gamma-glutamyl transferase.