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. Author manuscript; available in PMC: 2025 Aug 15.
Published in final edited form as: Sci Transl Med. 2024 Nov 20;16(774):eadl2184. doi: 10.1126/scitranslmed.adl2184

Fig. 3. Vagal protection against colitis is partially dependent on α7nAChR.

Fig. 3.

Time course of (A) DAI, (B) body weight, and (C) representative colons, (D) group colon lengths and weight, (E) intestinal permeability, and (F) colon immune cytokines in (A to F) Chrna7-KO (α7KO) or wild-type (WT) littermates at day 7 after 5-day DSS challenge. Time course of (G) DAI, (H) body weight, and (I) representative colons, (J) group colon lengths and weight, (K) intestinal permeability, and (L) colon immune cytokines in (G to L) Chrna7-KO (α7KO) mice at day 7 after receiving sham or vagal stimulation (VS) immediately followed by 5-day DSS challenge. *P<0.05 vs Control, #P<0.05 vs WT or DSS (n=4, One-way ANOVA with Bonferroni’s post-hoc test). Graphs represent the mean ± SEM of experiments repeated twice on different dates.