TABLE 2.

Lessons Learned and Research Considerations From 5 Ending the HIV Epidemic in the United States Supplement Projects Focused on AYA

Lesson	Application	Lessons Learned	Research Considerations
1. Reach and dissemination: use multiple, nimble, and creative methods to reach and disseminate information to AYA throughout the study’s life as needed	Recruitment for research and programs Dissemination of health information to educate clients	Need multiple online social platforms Use a combination of epidemiologic data and succinct, clear behavioral change messaging Provide tips on how to check for credible information online Use same ads across sites and with quick response, or QR, codes for online information	Pilot test advertisements for image inclusivity, preferred language, and color schemes Pilot test social media influencers to ensure authenticity Rotate schedule for posting advertisements across sites Use multiple languages Use health communication theory, A/B testing, and demand creation to engage audiences
2. Engagement: engage AYA meaningfully into projects using both digital and inperson approaches to improve trust and buy-in	Promote behavior change and dispel misinformation	Include portal or link to access health care providers and submit questions Consider the role of digital storytelling and arts-based methods for engaging AYA in health behavior change interventions Provide information about data security and safety in use of artificial intelligence tools	Ongoing maintenance and update of information and data Relevant to multiple methods for HIV prevention, testing, and treatment Offer signing up for listservs to hear about study updates, research results, and other paid opportunities Consider low-cost platforms with open access to public facing documents Ensure intervention can be accessed online and offline Get AYA input on how to ensure privacy Make tools feel less clinical, more customizable
3. Compensation: consider “payment” broadly and offer AYA not only equitable compensation for their time but also build in nonmonetary benefits to support youth	Promote ongoing retention because of study’s social benefits beyond monetary compensation Motivate pre-exposure prophylaxis or antiretroviral therapy use and build habits	Consider the role of social engagement as a facilitator of ongoing involvement in programs or studies Conduct needs assessment with focal audience to identify ideal nonmonetary compensation Financial incentives are more effective when combined with other strategies such as reminders	Stagger access to incentives to correspond with all activities Consider certificates of completion and sharing language about study activities that AYA can include on resumes and discuss in job interviews Advocate for cash payments wherever possible with minimized paperwork Get input from AYA on timing, structure, and mode of incentives and what other support is needed in combination to build habits