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. 2025 Aug 13;15(8):e097359. doi: 10.1136/bmjopen-2024-097359

Table 3. Univariate and multivariate logistic regression models for the association between CCI score and incidence of the in-hospital primary and secondary outcomes (CCI <3 used as reference).

The impact of CCI on in-hospital outcomes OR (95%CI) P value*
The impact of CCI on in-hospital mortality
 Model 1: unadjusted 0.83 (0.36 to 1.94) 0.67
 Model 2: adjusted for age, sex, smoking, drinking 0.81 (0.34 to 1.90) 0.62
 Model 3: adjusted for age, sex, smoking, drinking, PCI, coronary angiography, Killip classification 0.72 (0.29 to 1.81) 0.48
 Model 4: adjusted for age, sex, smoking, drinking, PCI, coronary angiography, Killip classification, GRACE score 0.8 (0.33 to 1.96) 0.63
The impact of CCI on in-hospital MACEs
 Model 1: unadjusted 3.06 (2.22 to 4.22) <0.001
 Model 2: adjusted for age, sex, smoking, drinking 3.1 (2.25 to 4.28) <0.001
 Model 3: adjusted for age, sex, smoking, drinking, PCI, coronary angiography, Killip classification 3.84 (2.69 to 5.49) <0.001
 Model 4: adjusted for age, sex, smoking, drinking, PCI, coronary angiography, Killip classification, GRACE score 3.89 (2.71 to 5.57) <0.001
The impact of CCI on length of stay
 Model 1: unadjusted 1.36 (1.07 to 2.03) <0.001
 Model 2: adjusted for age, sex, smoking, drinking 1.41 (0.75 to 2.07) <0.001
 Model 3: adjusted for age, sex, smoking, drinking, PCI, Coronary angiography, Killip classification 1.39 (0.73 to 2.04) <0.001
 Model 4: adjusted for age, sex, smoking, drinking, PCI, Coronary angiography, Killip classification, GRACE score 1.34 (0.68 to 1.99) <0.001
The impact of CCI on readmission
 Model 1: unadjusted 1.29 (1.03 to 1.63) 0.028
 Model 2: adjusted for age, sex, smoking, drinking 1.28 (1.02 to 1.62) 0.035
 Model 3: adjusted for age, sex, smoking, drinking, PCI, coronary angiography, Killip classification 1.29 (1.02 to 1.63) 0.035
 Model 4: adjusted for age, sex, smoking, drinking, PCI, coronary angiography, Killip classification, GRACE score 1.28 (1.01 to 1.62) 0.041
*

Statistically significant results (p<0.05) are displayed in bold.

CCI, Charlson Comorbidity Index; MACEs, major adverse cardiovascular events.