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Pedigree of family affected with dominantly inherited periodic-fever syndrome. One affected member of the family was screened for the TNFRSF1A mutation, throughout the coding and promoter regions; no mutation was identified. Linkage analysis was done to rule out other mutations in TNFRSF1A. Genotypes for six DNA markers from chromosome 12p are shown. Affected sibs in the second generation inherited opposite haplotypes across the interval.
