Table 3.
Genotypes of Three SNPs in PG1 in Probands, Unrelated Case Subjects, and Unaffected Control Subjects (White Subjects Only)
|
Case Subjects (%) |
Odds Ratioa (95% CI) |
|||||
| SNP andGenotype | Control Subjects (%) | Sporadic | HPC | Sporadic Case Subjects vs. Control Subjects | HPC Case Subjects vs. Control Subjects | All Case Subjects vs. Control Subjects |
| SNP 477: | n=178 | n=222 | n=123 | |||
| C/C | .47 | .46 | .46 | 1 | 1 | 1 |
| C/G | .44 | .41 | .42 | 1.06 (.70–1.60) | .96 (.59–1.58) | 1.03 (.70–1.51) |
| G/G | .09 | .13 | .12 | 1.38 (.69–2.74) | 1.36 (.61–3.04) | 1.39 (.73–2.63) |
| Any G | 1.11 (.75–1.65) | 1.03 (.64–1.64) | 1.09 (.76–1.57) | |||
| SNP 99217: | n=177 | n=217 | n=131 | |||
| C/C | .49 | .51 | .47 | 1 | 1 | 1 |
| C/T | .42 | .36 | .41 | .97 (.64–1.48) | .99 (.61–1.61) | .99 (.67–1.44) |
| T/T | .08 | .13 | .11 | 1.20 (.59–2.45) | 1.33 (.60–2.97) | 1.25 (.65–2.41) |
| Any T | 1.01 (.68–1.51) | 1.05 (.66–1.67) | 1.03 (.72–1.48) | |||
| SNP 467: | n=177 | n=212 | n=120 | |||
| G/G | .59 | .59 | .60 | 1 | 1 | 1 |
| G/A | .34 | .32 | .32 | 1.10 (.72–1.69) | .92 (.55–1.54) | 1.03 (.69–1.53) |
| A/A | .07 | .10 | .08 | 1.30 (.60–2.84) | 1.20 (.49–2.93) | 1.28 (.63–2.63) |
| Any A | 1.14 (.76–1.71) | .97 (.60–1.57) | 1.08 (.74–1.56) | |||
a
All odds ratios were adjusted for age.