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. 2001 Jun 29;69(2):381–395. doi: 10.1086/321297

Figure 1.

Figure 1

Genomic structure, variant mapping to BV genomic structure, and variant mapping to TCRB structure. A, TCRB spans 667 kb and contains 65 variable (V) segments; the diversity, joining, and constant (DJC) segments of the T-cell receptor, as well as several trypsinogen (Try) genes, and a dopamine-β-hydroxylase-like-pseudogene (Do). B, Numbers below the figure denote variants found within each gene feature: promoter, exon 1 and 2, intron and the recombination-signal sequence (RSS). For exons, the first number in parentheses indicates nonsynonymous changes in both pseudogene and functional V segments combined, and the second number indicates nonsynonymous changes in functional V segments only. Arrows indicate the PCR primers. C, Variants mapped to the TCRB structural features: leader peptide (LDR), framework regions (FR1, FR2, FR3), and complementarity-determining regions (CDR1, CDR2, and CDR3). The number of nonsynonymous changes in functional V segments is provided below each structural feature.