Figure 4.

LD in TCRB. A, LD (r²) observed across the TCRB locus for sites common to all four populations having minor-allele frequencies ⩾.1 plotted against distance. Filled circles indicate r² for individual site pairs. Large red circles denote the average r² in 5-kb bins. B, Same as in panel A, except the SNPs used to calculate LD are simulated using a coalescent model that replicates the observed sampling procedure. C, Distribution of LD. In the upper right hand triangle the darkened squares indicate statistically significant LD (P<.01); In the lower left triangle, the darkened squares indicate complete LD (i.e. <4 haplotypes are observed).