Table 2.

Maternal MTHFR Polymorphisms in Maternally Derived Cases of Trisomies 2, 7, 10, 13, 14, 15, 16, or 22 and in Control Individuals

	No. (%) of Individuals with MTHFR Polymorphisms
Study Population	CC	CT	TT	Case vs. Control “Susceptible” Genotypes (CT or TT)a
Trisomy:
2	2	7	1	χ2=2.20; NS
7	6	2	2	χ2=.66; NS
10	2	2	1	χ2=.06; NS
13	14	11	2	χ2=.25; NS
14	2	5	1	χ2=1.23; NS
15	10	10	0	χ2=.99; NS
16	30	27	5	χ2=.07; NS
22	7	9	0	χ2=.02; NS
Total (n=158)	73 (46.2)	73 (46.2)	12 (7.6)	χ2=.01; NS
Controls (n=48)	22 (47.8)	22 (47.8)	4 (8.3)

^aNS = not significant.