Table 4.
Maternal MTRR Polymorphisms in Maternally Derived Cases of Trisomies 2, 7, 10, 13, 14, 15, 16, or 22 and in Control Individuals
|
No. (%) of Individuals with MTRR Genotype |
||||
| Study Population | AA | AG | GG | Case vs. Control “Susceptible Genotype” (GG)a |
| Trisomy: | ||||
| 2 | 1 | 6 | 3 | χ2=0.54; NS |
| 7 | 1 | 5 | 1 | χ2=0.12; NS |
| 10 | 0 | 3 | 2 | χ2=1.11; NS |
| 13 | 8 | 9 | 9 | χ2=2.00; NS |
| 14 | 1 | 7 | 0 | χ2=1.88; NS |
| 15 | 2 | 9 | 5 | χ2=0.93; NS |
| 16 | 16 | 35 | 15 | χ2=0.16; NS |
| 22 | 2 | 13 | 1 | χ2=1.56; NS |
| Total (n=154) | 31 (20.1) | 87 (56.5) | 36 (23.4) | χ2=0.29; NS |
| Controls (n=46) | 11 (23.9) | 26 (56.5) | 9 (19.6) | … |
a
NS = not significant.