Table 3.
Multipoint HLOD Scores for 2q21 According to Phenotypic Breakdown
| Phenotypic Category | No. ofFamilies | HLOD | EstimatedProportionwith Linkage | NPL Score(P Value) | Position ofMaximumHLOD |
| All families: | 80 | 3.07 | .42 | 3.19 (.001) | D2S2271 |
| Cancer-only model | 2.34 | .42 | 2.53 (.006) | ||
| fvPTC: | 17 | 4.17 | .80 | 4.61 (.00006)a | AFMa272zg9 |
| Cancer-only model | 3.04 | .80 | 3.66 (.0003)a | ||
| PTC only: | 48 | .52 | .38 | 1.46 (.07) | D2S2224 |
| Cancer-only model | .34 | .35 | 1.27 (.1) | ||
| Unknown histopathology | 15 | 0 | 0 | −.08 (.5) |
a
NPL and P values at marker AFMa272zg9 (the point of maximum HLOD score). Using the 17 families, the maximal NPL score was 4.99 (P=.00002); for the cancer-only model, NPL score 4.40 (P=.00003) was achieved at marker D2S2271.