Table 1.
Chromosome 7 Linkage Analysis: Two-Point Parametric LOD Scores and Corresponding θ's for Three Families with Chordoma
|
LOD Score (θ) for |
|||||
| Penetrance |
|||||
| Marker | Genetic-MapPositiona(cM) | Affecteds Only | 100% | 75% | 50% |
| D7S1842 | 170.3 | .59 (.2) | .20 (.4) | .29 (.3) | .41 (.3) |
| D7S2203 | 172.7 | .38 (.2) | .23 (.3) | .39 (.2) | .42 (.2) |
| D7S530 | 178.2 | 1.29 (.1) | .89 (.2) | 1.03 (.2) | 1.17 (.1) |
| D7S512 | 179.7 | .92 (.1) | .29 (.2) | .68 (.1) | .83 (.1) |
| D7S1804b | 180.6 | 3.62 (0) | .98 (.2) | 2.02 (.01) | 3.08 (0) |
| D7S631 | 182 | 1.47 (0) | 1.24 (.1) | 1.13 (.05) | 1.19 (.05) |
| D7S500 | 184.2 | 4.05 (0) | 1.29 (.2) | 2.19 (.05) | 3.17 (0) |
| D7S509 | 186.9 | 4.01 (0) | 2.73 (.1) | 3.11 (.05) | 3.67 (0) |
| D7S495 | 188.3 | 1.54 (0) | .57 (.2) | .80 (.1) | 1.05 (.05) |
| D7S684 | 190.8 | 1.69 (.05) | .27 (.3) | .67 (.2) | 1.20 (.1) |
| D7S2505 | 191.7 | 3.53 (0) | 1.18 (.2) | 1.70 (.1) | 2.57 (0) |
| D7S2202 | 193.5 | 3.20 (0) | .77 (.2) | 1.48 (.1) | 2.31 (0) |
| D7S1824 | 193.5 | 2.20 (.05) | .49 (.3) | 1.16 (.1) | 1.75 (.05) |
| D7S2513 | 194.8 | 3.14 (.05) | 1.03 (.2) | 1.84 (.1) | 2.45 (.05) |
| D7S2195 | 200.1 | 2.85 (.05) | 1.39 (.2) | 2.04 (.1) | 2.46 (.05) |
| D7S661 | 202.1 | 1.62 (.05) | .15 (.3) | .54 (.2) | 1.05 (.1) |
| D7S1798 | 202.7 | .47 (.2) | .05 (.3) | .21 (.2) | .35 (.2) |
| D7S2511 | 203.3 | 2.51 (.05) | 1.59 (.2) | 1.94 (.1) | 2.16 (.1) |
| D7S688b,c | 206.5 | .54 (.2) | .35 (.2) | .43 (.2) | .49 (.2) |
| D7S2426 | 207 | 1.28 (.1) | .27 (.3) | .36 (.3) | .60 (.2) |
| D7S505 | 217.5 | .38 (.2) | .09 (.4) | .16 (.3) | .24 (.3) |
a
Based on the Center for Medical Genetics (Marshfield Medical Research Foundation) gender-averaged genetic map. Marker order was confirmed by reference to a physical map (Bouffard et al. 1997).
b
Allele frequencies were not available from either CEPH (Fondation Jean Dausset) or the Center for Human Genetics (Duke University Medical Center) and, therefore, are assumed to be equal.
c
Family 1 only.