Figure 1.

Sample AGRE pedigree. A typical AGRE pedigree is depicted, with the identifying numbers given directly underneath the individuals. The second number refers to the following key, as defined by ADI scores: 1 = verbal; 2 = nonverbal; 3 = regression; and 4 = late onset. The HI numbers are actual coded database numbers that uniquely identify each individual. The availability of biomaterials is also indicated if the family was corecruited with another academic group—in this case, Mt. Sinai (AGRE Web site).