Table 1.
Summary of Parental Contributions to IBD Sharing in ASPs[Note]
|
ASPEX MLS of IBD Sharing in |
||||||||
| Broad ASPs |
Narrow ASPs |
|||||||
| Chromosome | cM | Locus | Paternal | Maternal | Overall | Paternal | Maternal | Overall |
| 5 | .0 | D5S2488 | 1.75 | .08 | 1.77 | 1.02 | .46 | 1.44 |
| 5 | 58.9 | D5S2494 | .38 | .86 | 1.23 | −.28 | 1.07 | .79 |
| 16 | 20.0 | D16S2619 | .78 | .66 | 1.44 | .40 | 1.38 | 1.76 |
| 18 | .0 | D18S59 | .44 | .25 | .68 | .68 | .47 | 1.15 |
| 19 | 32.0 | D19S714 | .20 | .94 | 1.15 | .62 | 1.25 | 1.90 |
| 19 | 61.5 | D19587- D18601 | .36 | .00 | .37 | 1.12 | −.31 | .79 |
Note.— Locus positions are indicated as centimorgan distance from a start point = 0, at pter. ASPs are categorized according to diagnostic criteria described in Families and Methods. Maternal and paternal contributions to IBD sharing were obtained using the ASPEX (sib-phase) program, as described in Statistical Analysis. MLS are depicted for multiplex families partitioned according to the likelihood (<50% vs. ⩾50%) of sharing maternal alleles at DXS1047.