Table 6.
Statistical analysis using a repeated measures 2-way analysis of variance or 3-way analysis of variance of ensure food acquisition of data presented in Figure 6.
| Figure 6 | F (DFn, DFd) | P | ||
|---|---|---|---|---|
| Ensure food | ||||
| Figure 6B FR1 |
Reinforcers Both sexes |
Time | F (6, 129) = 23.25 | P < 0.0001**** |
| Pain | F (1, 22) = 1.439 | P = 0.2431 | ||
| Interaction | F (6, 129) = 0.2529 | P = 0.9573 | ||
| Reinforcers Males |
Time | F (3.176, 31.76) = 11.72 | P < 0.0001**** | |
| Pain | F (1, 10) = 2.287 | P = 0.1614 | ||
| Interaction | F (6, 60) = 0.2059 | P = 0.9736 | ||
| Reinforcers Females |
Time | F (2.741, 26.04) = 11.21 | P < 0.0001**** | |
| Pain | F (1, 10) = 0.1585 | P = 0.6989 | ||
| Interaction | F (6, 57) = 1.219 | P = 0.3099 | ||
| Figure 6C FR1 | Nose pokes | Time | F (9, 99) = 28.08 | P < 0.0001**** |
| Nose poke | F (1, 11) = 91.29 | P < 0.0001**** | ||
| Pain | F (1, 11) = 0.2100 | P = 0.6557 | ||
| Time × nose poke | F (9, 99) = 7.760 | P < 0.0001**** | ||
| Time × pain | F (9, 99) = 0.8956 | P = 0.5323 | ||
| Nose poke × pain | F (1, 11) = 2.026 | P = 0.1824 | ||
| Time × nose poke × pain | F (9, 25) = 0.7876 | P = 0.6301 | ||
| Figure 6D Intersession cumulative reinforcers |
AUC | Day 3 | t = 2.934, df = 18 | P = 0.0089*** |
| Day 5 | t = 2.970, df = 19 | P = 0.0079** | ||
| Day 5 Males |
Time × pain | F (120, 2520) = 2.111 | P < 0.0001**** | |
| Time | F (2.317, 48.65) = 56.78 | P < 0.0001**** | ||
| Pain | F (1, 21) = 4.227 | P = 0.0524 | ||
| Day 5 Females |
Time × pain | F (120, 2520) = 1.330 | P = 0.0109* | |
| Time | F (2.311, 48.53) = 49.66 | P < 0.0001**** | ||
| Pain | F (1, 21) = 2.648 | P = 0.1186 | ||
| Figure 6E FR3 | Reinforcers Both sexes |
Time × pain | F (4, 107) = 0.3334 | P = 0.8550 |
| Time | F (2.196, 46.65) = 1.917 | P = 0.1548 | ||
| Pain | F (1, 22) = 0.04718 | P = 0.8300 | ||
| Nose poke Both sexes |
Time | F (7, 77) = 0.4868 | P = 0.8414 | |
| Nose poke | F (1, 11) = 1137 | P < 0.0001**** | ||
| Pain | F (1, 11) = 0.9074 | P = 0.3613 | ||
| Time × nose poke | F (7, 77) = 1.619 | P = 0.1428 | ||
| Time × pain | F (7, 77) = 0.6145 | P = 0.7423 | ||
| Nose poke × pain | F (1, 11) = 1.047 | P = 0.3282 | ||
| Time × nose poke × pain | F (7, 7) = 0.7977 | P = 0.6134 | ||
| Figure 6F Progressive ratio |
Break point | Pain | F (1, 20) = 0.1870 | P = 0.6701 |
| Sex | F (1, 20) = 0.7723 | P = 0.3899 | ||
| Pain × sex | F (1, 20) = 0.2384 | P = 0.6307 | ||
| Figure 6G FR1 reversal |
Reinforcers | Time × pain | F (9, 178) = 0.7763 | P = 0.6385 |
| Time | F (1.925, 38.07) = 2.221 | P = 0.1241 | ||
| Pain | F (1, 22) = 1.412 | P = 0.2474 | ||
| Nose pokes | Time | F (9, 99) = 52.85 | P < 0.0001**** | |
| Nose poke | F (1, 11) = 153.9 | P < 0.0001**** | ||
| Pain | F (1, 11) = 0.05763 | P = 0.8147 | ||
| Time × nose poke | F (9, 99) = 67.80 | P < 0.0001**** | ||
| Time × pain | F (9, 99) = 1.014 | P = 0.4341 | ||
| Nose poke × pain | F (1, 11) = 0.2603 | P = 0.6200 | ||
| Time × nose poke × pain | F (9, 59) = 1.344 | P = 0.2348 | ||
| Magazine Entries |
Time × pain | F (10, 174) = 0.6821 | P = 0.7402 | |
| Time | F (4.484, 78.03) = 8.614 | P < 0.0001**** | ||
| Pain | F (1, 22) = 0.3819 | P = 0.5430 |
An unpaired t test was used for area under the curve (AUC) data. Cumulative reinforcers were analyzed by a repeated measures 2-way repeated ANOVA. P values are provided for each of the factors (time, pain, and appropriate interactions) for active and inactive nose pokes, and number of reinforcers earned. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001.
AUC, area under the curve; FR, fixed ratio.