Why carry out this study?

Androgen-induced excess sebum production by the sebaceous glands is an important early step in the pathophysiology of acne.

Clascoterone cream 1% decreases androgen-stimulated sebum production in vitro; however, the exact mechanism of action of clascoterone cream 1% for the treatment of acne is unknown.

This study aimed to demonstrate the effect of clascoterone cream 1% on facial casual sebum production as well as acne severity in patients with acne vulgaris.

What was learned from the study?

Significant reductions from baseline were observed in sebum measurements, Investigator’s Global Assessment score, lesion counts, and subjective facial characteristics (oily appearance, pore size, and shine) following treatment with clascoterone cream 1%, and no tolerability or safety issues were identified.

This study shows that clascoterone cream 1% decreases casual sebum production and provides further evidence of its efficacy as a topical option for treating androgen-stimulated excess sebum production in male and female patients with acne.