Table 1.
Positions of SNP Markers Displaying Reproducibly Positive Association with Polysubstance Abuse in the Current Study and of SSLPs Nominally Positive in Prior Linkage Studies of Alcohol or Nicotine Dependence[Note]
|
Distance |
Abuser/Control Ratio |
|||||
| Chromosomeand WIAFor SSLPNumber | AveragedRadiationHybrid | MapviewerBuild 22 | MapviewerBuild 24 | SubmittedSequenceNumberor Reference | EuropeanAmerican | AfricanAmerican |
| 1: | ||||||
| D1S548 | 5.2 | 7.1 | Reich et al. 1998 | |||
| WIAF-944 | 69 | 30.1 | 32.2 | 3043 | 1.23 | 1.41 |
| D1S1598 | 33.2 | 38.6 | Reich et al. 1998 | |||
| D1S532 | 82.6 | 80.8 | Reich et al. 1998 | |||
| D1S1588 | 109.5 | 95.6 | Reich et al. 1998 | |||
| D1S1592 | 118.3 | 127.8 | Reich et al. 1998 | |||
| WIAF-1018 | 208.6 | 184.3 | 177 | 3117 | .89 | 1.22 |
| WIAF-952 | 242.2 | 194.7 | 211.2 | 3051 | 1.3 | 1.25 |
| 2: | ||||||
| D2S114 | 134.1 | 129.5 | Straub et al. 1999 | |||
| D2S1326 | 142.5 | 135 | Straub et al. 1999 | |||
| D2S426 | 197.3 | 185.2 | Reich et al. 1998 | |||
| WIAF-1942 | 124.7 | 209.6 | 208.1 | 3487 | .84 | 1.38 |
| WIAF-1700 | 248.3 | 234.8 | 229.7 | 2052 | 1.2 | 1.31 |
| 3: | ||||||
| D3S2403 | 16.1 | 15.9 | Long et al. 1998 | |||
| WIAF-1765 | 44.5 | 24.5 | 27.7 | 3312 | 1.12 | 1.4 |
| D3S2432 | 29.5 | 32.4 | Long et al. 1998 | |||
| WIAF-4560 | 125 | 50.9 | 54.3 | 19367 | .84 | .82 |
| WIAF-1473 | 143.3 | 126.6 | 125.4 | 1092 | 1.14 | 1.22 |
| WIAF-3407 | 135.3 | 130.4 | 133.8 | 19294 | 1.12 | 1.31 |
| D3S1746 | 164.1 | 156.5 | Long et al. 1998 | |||
| D3S1763 | 175.8 | 172.9 | Long et al. 1998 | |||
| D3S3053 | 184.4 | 176.6 | Long et al. 1998 | |||
| WIAF-847 | 187.1 | 185.4 | 177 | 2948 | .79 | .78 |
| WIAF-250 | 207.2 | 191.3 | 191.3 | 2605 | .83 | .72 |
| 4: | ||||||
| D4S2382 | 37.3 | 25.1 | Long et al. 1998 | |||
| D4S2632 | 44.3 | 36.4 | Long et al. 1998 | |||
| D4S1647 | 109 | 37.4 | Long et al. 1998 | |||
| D4S2457 | 109 | 37.4 | Reich et al. 1998 | |||
| D4S174 | 49.6 | 41.9 | Long et al. 1998 | |||
| D4S2456 | 81.1 | 43.5 | Long et al. 1998 | |||
| D4S1627 | 51.4 | 45.8 | Long et al. 1998 | |||
| WIAF-452 | 60.9 | 51.6 | 45.9 | 2739 | 1.16 | 1.57 |
| D4S1645 | 66.4 | 60.7 | Long et al. 1998 | |||
| D4S244 | 71.5 | 64.2 | Reich et al. 1998 | |||
| D4S2393 | 81.8 | 74.3 | Reich et al. 1998 | |||
| WIAF-2114 | 98.5 | 93.8 | 83.4 | 1227 | .81 | .71 |
| WIAF-373 | 100 | 102.8 | 90 | 2688 | 1.34 | 1.44 |
| ADH3 | 107.1 | 97 | Reich et al. 1998 | |||
| D4S3256 | 118.6 | 104.5 | Long et al. 1998 | |||
| D4S3240 | 116.8 | 106.6 | Long et al. 1998 | |||
| WIAF-2765 | 109.7 | 110.7 | 110.9 | 19501 | .78 | .73 |
| WIAF-3818 | 125.8 | 139 | 122.6 | 1879 | .84 | 1.29 |
| WIAF-3821 | 127.8 | 139 | 122.6 | 1882 | .85 | 1.63 |
| 5: | ||||||
| WIAF-3575 | 62.8 | 54 | 49.8 | 1636 | 1.19 | 1.32 |
| WIAF-1869 | 81.5 | 68.3 | 69.5 | 3414 | .86 | 1.32 |
| D5S2501 | 105.6 | 105.9 | Long et al. 1998 | |||
| 6: | ||||||
| WIAF-1567 | 20.5 | 16.9 | 12.1 | 1124 | 1.12 | 1.56 |
| WIAF-2177 | 41.9 | 37.7 | 36.4 | 1290 | 1.22 | 1.28 |
| D6S1018 | 51.4 | 51.2 | Reich et al. 1998 | |||
| 7: | ||||||
| D7S531 | 2.1 | 2.9 | Long et al. 1998 | |||
| D7S1793 | 49.2 | 50.3 | Reich et al. 1998 | |||
| WIAF-1680 | 126.5 | 104.6 | 104.6 | 1168 | .85 | 1.25 |
| D7S1809 | 127.4 | 121.1 | Reich et al. 1998 | |||
| 8: | ||||||
| D8S549 | 14.9 | 15.7 | Reich et al. 1998 | |||
| D8S280 | 20.8 | 20.6 | Reich et al. 1998 | |||
| WIAF-1291 | 107 | 100.1 | 93.6 | 934 | 1.23 | 1.25 |
| WIAF-989 | 147.7 | 131.3 | 130.5 | 3088 | .89 | .75 |
| 9: | ||||||
| WIAF-1900 | 49.8 | 30.3 | 28.5 | 3445 | 1.16 | 1.27 |
| D9S319 | 28.3/31.4 | 30.8 | Long et al. 1998 | |||
| WIAF-3477 | 125.8 | 108.6 | 109.9 | 1538 | .85 | 1.35 |
| 10: | ||||||
| D10S1435 | 2.2 | 2.1 | Long et al. 1998 | |||
| WIAF-3336 | 85.6 | 52.5 | 60.3 | 19256 | 1.17 | .77 |
| D10S677 | 102.4 | 98 | Straub et al. 1999 | |||
| D10S1239 | 108.7 | 105.6 | Straub et al. 1999 | |||
| WIAF-268 | 137.3 | 114.4 | 109.5 | 19487 | 1.18 | 1.21 |
| D10S2469 | 114.4 | 109.5 | Straub et al. 1998 | |||
| 11: | ||||||
| D11S1984 | 1.4 | .3 | Long et al. 1998 | |||
| D11S2368 | 15.3 | 17.8 | Long et al. 1998 | |||
| AFM333TH1 | 17.7 | 17.1/18.1 | Reich et al. 1998 | |||
| WIAF-2046 | 39.1 | 25.9 | 25.5 | 3585 | 1.28 | 1.36 |
| WIAF-1949 | 40 | 28.1 | 28.3 | 3494 | 1.18 | 1.47 |
| D11S1392 | 35.4 | 34.4 | Long et al. 1998 | |||
| D11S976 | 128.1 | 122.4 | Long et al. 1998 | |||
| D11S2359 | 144.8 | 140.5 | Reich et al. 1998 | |||
| 12: | ||||||
| D12S393 | 104.1 | 100.7 | Reich et al. 1998 | |||
| WIAF-364 | 153.2 | 133.9 | 129.3 | 2681 | .83 | .71 |
| WIAF-3624 | 146.3 | 134.6 | 129.1 | 1685 | .85 | 1.22 |
| D12S1045 | 140 | 136 | Reich et al. 1998 | |||
| 13: | ||||||
| D13S321 | 58.2 | 56.1 | Reich et al. 1998 | |||
| D13S762 | 96.5 | 90.8 | Reich et al. 1998 | |||
| WIAF-4520 | 29.9 | 94.8 | 93.5 | 19336 | 1.13 | 1.42 |
| WIAF-2555 | 96.6 | 91.3 | 114.1/115.5 | 2068 | 1.13 | .78 |
| D13S285 | 92.2 | 115.1 | Long et al. 1998 | |||
| WIAF-600 | 80.8 | 102.5 | 101.5 | 2197 | .86 | 1.23 |
| D13S895 | 111.5 | 110.6 | Long et al. 1998 | |||
| 15: | ||||||
| D15S153 | 65.2 | 62.5 | Long et al. 1998 | |||
| D15S642 | 99 | 99 | Reich et al. 1998 | |||
| 16: | ||||||
| D16S675 | 9.13 | 7 | Reich et al. 1998 | |||
| GATA5H07 | NA | NA | Long et al. 1998 | |||
| D16S422 | 84.4 | 86.1 | Straub et al. 1999 | |||
| 17: | ||||||
| D17S1308 | 1.7 | .2 | Long et al. 1998 | |||
| WIAF-3343 | 77 | 61.9 | 67.4 | 1416 | .88 | .8 |
| D17S2059 | 70.7 | 71.3 | Straub et al. 1999 | |||
| D17S1535 | 74.8 | 75.6 | Long et al. 1998 | |||
| 18: | ||||||
| D18S869 | 21.4 | 19 | Straub et al. 1999 | |||
| WIAF-303 | 65.9 | 51.1 | 50.7 | 2127 | 1.14 | 1.52 |
| D18S844 | 76.2 | 77.4 | Long et al. 1998 | |||
| 19: | ||||||
| WIAF-2426 | 35 | NA | NA | 3698 | 1.32 | 1.46 |
| D19S49 | 40.7 | 44.1 | Reich et al. 1998 | |||
| 21: | ||||||
| WIAF-4514 | 43 | 31.7 | NA | 19393 | 1.14 | 1.21 |
| 22: | ||||||
| WIAF-3065 | 43.2 | 42.8 | 43.3 | 19273 | 1.12 | 1.55 |
| X: | ||||||
| WIAF-2589 | 156.1 | 117.4 | 123.1 | 3824 | 1.13 | 1.28 |
| DXS8061 | 138.4 | 147.5 | Straub et al. 1998 | |||
| WIAF-1743 | 187.7 | 138.8 | 147.8 | 3290 | .89 | .75 |
| Not placed: | ||||||
| D4S3242 | NA | Long et al. 1998 | ||||
Note.— Reproducibly positive SNPs from the current study and simple sequence–length repeat markers displaying nominally significant linkage in prior affected sib-pair linkage studies of alcohol or nicotine dependence. Reproducibly positive SNPs with abuser/control ratios in the upper or lower 5% of values in the European American sample and in the upper or lower 7.5% in the African American sample are listed here. SNP markers are identified by WIAF numbers (column 1). Markers are listed along with their chromosomal assignments (column 1), averaged radiation hybrid distances (column 2) in cM, ratio of A/B alleles in substance abusers divided by those for control individuals in the European American (column 7) and African American (column 8) sample pools (see Methods). Mapviewer chromosomal positions (expressed in Mb) of SNPs use build 22 and build 24. Markers whose data are shown in boldface italics lie near other positive markers in build 24. Two pairs of markers, D4S2457/D4S1647 and WIAF-3818/WIAF-3821, sample the same two underlying polymorphisms. Underlining indicates differently named assays that sample the same underlying sequence variations.