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. 2025 Jun 21;7(9):101480. doi: 10.1016/j.jhepr.2025.101480

Table 2.

Causes and potential solutions to improve liver-related outcomes related to the alcohol-harm paradox.

Influences of liver health on the AHP Causes Possible remedies
Alcohol consumption patterns
  • Increased binging episodes have a more harmful impact on the liver than gradual alcohol intake

  • Lower income individuals more likely to choose spirits or beer over wine

  • Higher alcohol outlet density in urban areas contributes to higher alcohol intake

Strengthen alcohol policy
  • Introduce pricing policies that make cheap, high-alcohol-content beverages less accessible

  • Limit alcohol marketing, particularly in low-income areas and to vulnerable populations

  • Reduce the concentration of alcohol outlets in disadvantaged neighbourhoods

Education
  • Insufficient public education and opportunities for individuals to seek help

  • Providers unaware of screening and treatment strategies for alcohol use disorder and ALD

Reduce stigma and enhance awareness
  • Educate about alcohol’s health risks, emphasizing liver disease, mental health, and chronic illnesses, e.g. US Surgeon General warning about alcohol and cancer risk

  • Train healthcare providers to address stigma, and deliver equitable care tailored to diverse socioeconomic backgrounds

  • Develop opportunities for education regarding treatment for alcohol use disorder and ALD

Healthcare access
  • Lower income groups, immigrants, and individuals living in densely populated urban areas are less likely to have health insurance or easy access to preventive health

  • Limited access to healthcare leads to delayed diagnosis of ALD, leading to more severe illness and limited treatment options

  • Limited access and lower health literacy make treatment adherence more challenging, reducing the likelihood of transplant listing

Improve access to healthcare
  • Implement routine screening for alcohol use and liver disease, especially in underserved areas

  • Provide affordable access to addiction treatment programmes, counselling, and medications for AUD

  • Expand access to mental health care

  • Ensure timely referral to subspecialty care

  • Leverage use of virtual visits or consults

Psychosocial stress and stigmatization
  • Chronic stress from unsafe living conditions, unstable housing, and/or financial insecurity may increase alcohol use as a coping mechanism

  • Progression of ALD from mild to severe illness and compounding symptoms and comorbidities may lead to further drinking

Reduce social determinants of poor health
  • Address financial insecurity through job training, housing assistance, and income support to reduce stress-related alcohol use

  • Improve housing access and living conditions

  • Reduce food insecurity and food deserts

Community engagement
  • Involve disadvantaged communities in designing and implementing interventions to ensure they are relevant and culturally appropriate

  • Provide early interventions for children and teenagers in high-risk environments to prevent harmful drinking patterns from developing