Table 3.—

Tissues with histiocytic cellular infiltration in F344/N rats and B6C3F1 mice.

Exposure concentration	Male rats	0 mg/L	14.3 mg/L	57.3 mg/L	172 mg/L	516 mg/L
	Female rats	0 mg/L	14.3 mg/L	57.3 mg/L	172 mg/L	516 mg/L
	Male mice	0 mg/L	14.3 mg/L	28.6 mg/L	85.7 mg/L	257.4 mg/L
	Female mice	0 mg/L	14.3 mg/L	57.3 mg/L	172 mg/L	516 mg/L
Liver	Male rats (N = 49–50)	1	0	2	5	34**
	Female rats (N = 50)	1	5	21**	42**	47**
	Male mice (N = 50)	1	3	4	4	3
	Female mice (N = 49–50)	2	15**	23**	32**	45**
Duodenum	Male rats (N = 46–48)	0	0	6*	36**	47**
	Female rats (N = 46–50)	0	0	1	30**	47**
	Male mice (N = 50)	0	2	4	37**	35**
	Female mice (N = 50)	0	0	4	33**	40**
Mesenteric lymph node	Male rats (N = 49–50)	13	11	30**	39**	41**
	Female rats (N = 50)	21	18	27	36**	42**
	Male mice (N = 46–49)	14	38**	31**	32**	42**
	Female mice (N = 46–50)	3	29**	26**	40**	42**
Pancreatic lymph node	Male rats (N = 32–36)	17	22	17	17	25
	Female rats (N = 29–36)	17	20	23	32**	27
	Male mice (N = 5–16)	0	2	2	5*	12**
	Female mice (N = 12–15)	0	1	2	7**	8**

Note: Significant by the poly-3 test at *p ≤ .05 or **p ≤ .01.