Table 3.

Diagnostic performance of the MASH Resolution Index (MASHResInd) to detect metabolic dysfunction-associated steatohepatitis resolution

	MASH resolution index
	Derivation cohort	Validation cohort
AUC	0.81, 95% CI 0.69 to 0.93	0.83, 95% CI 0.76 to 0.91
Cut-off	MASHResInd≤−2.67	MASHResInd≤−2.67
N	27	17
Sensitivity	88.9%	100.0%
Specificity	32.5%	12.7%
PPV	23.5%	19.9%
NPV	92.6%	100.0%
Grey zone, N (%)	50 (52.6%)	57 (35.0%)
Cut-off	MASHResInd≥−0.67	MASHResInd≥−0.67
N	18	89
Sensitivity	55.6%	89.7%
Specificity	89.6%	53.0%
PPV	55.6%	29.2%
NPV	89.6%	95.9%

AUC, area under the receiver operating curve; MASH, metabolic dysfunction-associated steatohepatitis; NPV, negative predictive value; PPV, positive predictive value.