Table 3. Univariate and multivariate analyses of factors influencing PFS and OS in NDMM patients.

Abbreviations: HR, hazard ratio; CI, confidence interval; CPCs, circulating plasma cells; Ig, immunoglobulin; Hb, haemoglobin; PLT, platelet count; ALB, albumin; LDH, lactate dehydrogenase; Cr, creatinine; β2-MG, beta-2 macroglobulin; DS, Durie-Salmon; R-ISS, Revised International Staging System; BMPC, bone marrow plasma cells.

	PFS				OS
Factors	Univariate analysis		Multivariate analysis		Univariate analysis		Multivariate analysis
	HR(95%CI)	P	HR(95%CI)	P	HR(95%CI)	P	HR(95%CI)	P
Sex<br>(Male vs Female)	0.898<br>(0.524–1.467)	0.634			1.231<br>(0.982–2.121)	0.216
Age≥65 years	1.006<br>(0.965–1.049)	0.778			1.382<br>(0.783–2.492)	0.321
Hb 100 g/L	0.529<br>(0.272–1.029)	0.061			0.891<br>(0.472–1.321)	0.051
ALB<35 g/L	1.782<br>(0.672–3.514)	0.350			2.133<br>(0.873–4.238)	0.193
LDH≥220 U/L	1.704<br>(1.257–2.843)	0.023	1.463<br>(1.003–2.189)	0.041	2.331<br>(1.342–4.839)	0.012	1.345<br>(0.923–1.832)	0.068
Ca>2.65 mmol/L	2.415<br>(0.981–5.124)	0.056			1.232<br>(0.843–2.537)	0.318
Cr≥177 μmol/L	1.325<br>(0.782–2.742)	0.072			1.453<br>(0.649–3.129)	0.672
β2-MG≥3.5 mg/L	2.345<br>(1.628–4.982)	0.019	1.774<br>(0.923–3.136)	0.225	2.421<br>(0.891–4.782)	0.381
DS Stage III	3.735<br>(1.056–8.206)	0.008	3.132<br>(1.039–7.385)	0.021	4.321<br>(1.324–7.342)	0.034	3.214<br>(1.292–6.432)	0.056
R-ISS Stage III	2.992<br>(1.246–8.181)	0.014	2.374<br>(0.927–6.237)	0.067	2.839<br>(0.932–4.516)	0.056
High-Risk<br>Cytogenetics	3.002<br>(1.782–5.409)	<0.001	2.671<br>(1.671–4.889)	0.004	4.219<br>(1.782–7.389)	<0.001	3.810<br>(1.572–6.892)	0.012
BMCP≥30%	3.232<br>(1.292–7.428)	0.039	2.772<br>(0.832–5.231)	0.178	2.412<br>(0.781–4.214)	0.267
CPCs≥0.0101%	5.548<br>(3.218–10.539)	<0.001	5.021<br>(2.328–8.323)	<0.001	5.289<br>(2.894–9.148)	0.002	4.249<br>(1.894–8.781)	0.043