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Detection of neutralizing antibodies against FMDV in cattle sera. Neutralizing antibody titers (ISN) were determined on bovine sera collected at day zero and at different times postinoculation with A24-RGD (a) and A24-SGD (A24-B9-like) (b) viruses (see Materials and Methods). The antigenic bilateral relationship (R value) between these viruses was determined by a cross-neutralization assay using polyclonal antisera obtained at 21 dpi from bovines 21 and 22.
