FIG. 1.

Effect of IFN treatment on LGTV replication in MNB cells. MNB cells were infected with LGTV virus (strain TP21; MOI of 1) and incubated for 72 h, at which time the virus titer in the supernatant was determined. Cells were either not treated with IFN (NT), pretreated with IFN for 24 h (−24 hr), or treated with IFN 4 h (+4hr) or 24 h (+24hr) after infection. Cells were treated with (A) IFN-α (1,000 U/ml), (B) IFN-γ (10 ng/ml), or (C) IFN-α plus IFN-γ. The error bars represent standard errors of the mean (SEMs) for three experiments. *, P < 0.05.