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. 2005 Oct;79(20):13028–13036. doi: 10.1128/JVI.79.20.13028-13036.2005

FIG. 1.

FIG. 1.

CADD of ITI-367. (A) Hypothetical structural pocket within the N-terminal NLS of HIV-1 MA protein. The amino acids shown (R22, K27, Y29, and H33) participate in the formation of the hypothetical binding pocket for ITI-367. (B) The chemical structure of ITI-367. (C) ITI-367 in its docked (hypothetical) conformation and orientation within the “tyrosine pocket” of HIV-1 MA. In this molecular model, the protein is rendered as a solid molecular surface (light gray/light blue) and ITI-367 is shown in space-filling representation (standard atom coloring: gray, carbon; blue, nitrogen; red, oxygen; green, fluorine).