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. 2005 Oct;79(20):13028–13036. doi: 10.1128/JVI.79.20.13028-13036.2005

FIG. 6.

FIG. 6.

ITI-367 inhibits HIV-1 PIC binding to importin α. Cytoplasmic lysates of HIV-1-infected cells were incubated with importin α immobilized on Sepharose beads in the presence of the indicated concentrations of ITI-367. The amount of importin α-associated HIV-1 DNA was quantified in triplicate by real-time PCR. Results are presented as means ± the standard errors of the means of the numbers of HIV-1 DNA copies. Empty Sepharose beads retained less than 15 DNA copies. The graph shows results of one representative experiment out of two performed.