FIG. 3.

Recombination across (panels B and C) and within (panels D and E) iVDPV lineages generating mosaic genomes. Panel A: Schematic of the poliovirus genome. The single ORF is represented by a rectangle, flanked by the 5′-UTR and 3′-UTR. Panels B and D: The most recent of the trio of isolates is represented as having the reference mosaic genome, with the sites of sequence discontinuity indicated by arrows. Sequence intervals of the reference mosaic genome most closely matching those of the preceding isolates are shaded accordingly. The 5′-UTR and 3′-UTR sequences were not included in the analyses for recombination and are represented only by lines. Panels C and E: Alignment of ORF nucleotide sites that are polymorphic among each trio of isolates. In each trio, the sequence of the most recent isolate is shown as a reference, with the sequence differences from that reference indicated below for the two preceding isolates. Polymorphic sites are numbered consecutively.