FIG. 7.
The effects of ST-246 and CDV on virus titers in liver, spleen, and lung at day 8 postinfection. A/NCr mice were inoculated with 50 PFU (100× LD50) of ectromelia virus via intranasal administration. CDV-treated mice were injected on day 0 with a single dose by the intraperitoneal route. ST-246- or placebo-dosed mice were treated by gavage on day 0 through day 14 at 8-h intervals and twice daily. At day 8 postinfection, five mice in each group were sacrificed, and tissue infectivity was measured in target organs by plaque assay.