Table 1.
Table of share genetic mutations between autism, Celiac disease and IBD from literature review. Abbreviations: single nucleotide polymorphism (SNP), pubmed identifier (PMID), methylenetetrahydrofolate reductase (MTHFR), ulcerative colitis (UC), crohn’s disease (CD), myosin IXB (MYO9B), transcobalamin 2 (TCN2), inflammatory bowel disease (IBD).
| Gene | SNP | Disease | Allele | PMID | Ethnicity | P-value |
|---|---|---|---|---|---|---|
| MTHFR | rs1801133 | Autism | T | 31,033,224 | Egyptian (Arab descent) | < 0.001 |
| 27,755,291 | South Asian (Indian descent) | < 0.0001 | ||||
| 23,653,228 | Caucasian | < 0.01 | ||||
| South Asian (Indian descent) | ||||||
| East Asian (Chinese descent) | ||||||
| European descent | ||||||
| Caucasian descent | ||||||
| Mixed | ||||||
| 22,648,721 | Hispanic | < 0.01 | ||||
| Asian | ||||||
| Non-Hispanic black | ||||||
| Non-Hispanic white | ||||||
| Mixed | ||||||
| Other | ||||||
| Celiac | T | 11,244,621 | European (French descent) | NR | ||
| UC | TT | 10,446,107 | European (Irish descent) | 0.01 | ||
| CD | T | 28,002,332 | Ashkenazi Jewish | 0.0027 | ||
| non-Ashkenazi Jewish | ||||||
| TT | 10,446,107 | European (Irish descent) | 0.02 | |||
| IBD | TT | 21,967,576 | Caucasian (Iranian descent) | 0.09 | ||
| TT | 10,446,107 | European (Irish descent) | 0.02 | |||
| T | 14,560,147 | European (Portuguese descent) | < 0.001 | |||
| MYO9B | rs1545620 | Autism | T | 35,215,271 | Arab descent | 8.44*10−6 |
| T/G | 32,996,047 | Arab descent | < 1.24*10−5 | |||
| Celiac | A/C/G | 26,628,973 | European | 0.001 | ||
| 17,967,566 | European (Dutch descent) | 0.04 | ||||
| UC | A/C/G | 27,435,931 | Caucasian | 0.001 | ||
| 17,087,940 | European (Dutch descent) | 0.028 | ||||
| European (British descent) | 0.0035 | |||||
| Italian and European Canadian descent | 0.015 | |||||
| T | 21,648,020 | East Asian (Chinese descent) | 0.017 | |||
| G | 17,944,996 | European (Italian descent) | 0.005 | |||
| CD | A/C/G | 27,435,931 | Caucasian | 0.001 | ||
| 17,087,940 | European (Dutch descent) | 0.019 | ||||
| European (British descent) | 0.038 | |||||
| C | 24,966,617 | East Asian (Chinese descent) | 0.42 | |||
| G | 17,944,996 | European (Italian descent) | 0.01 | |||
| IBD | C | 27,556,856 | East Asian (Chinese descent) | 0.793 | ||
| Caucasian | 0.301 | |||||
| CC | 27,556,856 | East Asian (Chinese descent) | 0.212 | |||
| Caucasian | < 0.001 | |||||
| A/C/G | 17,087,940 | European (Dutch descent) | 1.9*10−6 | |||
| European (British descent) | ||||||
| Canadian/Italian | ||||||
| G | 17,944,996 | European (Italian descent) | 0.001 | |||
| TCN2 | rs1801198 | Autism | C | 30,676,283 | South Asian (Indian descent) | 0.009 |
| CG | 30,676,283 | South Asian (Indian descent) | 0.005 | |||
| Celiac | - | - | - | - | ||
| UC | G | 28,526,947 | East Asian (Chinese descent) | < 0.001 | ||
| CG + GG | 28,526,947 | East Asian (Chinese descent) | < 0.001 | |||
| CD | G | 28,472,811 | East Asian (Chinese descent) | < 0.05 | ||
| CG + GG | 28,472,811 | East Asian (Chinese descent) | < 0.05 |