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. 2025 Aug 16;15(8):e093896. doi: 10.1136/bmjopen-2024-093896

Table 4. Multiplicative and additive interactions between childhood health and childhood SES on dementia risk.

Interaction type Measure Estimate (95% CI) P value
Multiplicative interaction (OR scale)
Unhealthy childhood (without interaction) 1.27 (0.99 to 1.63) 0.061
Poor SES (without interaction) 1.42 (1.00 to 2.01) 0.048
Unhealthy childhood (with interaction) 1.44 (0.51 to 4.09) 0.496
Poor SES (with interaction) 1.44 (1.00 to 2.09) 0.052
Interaction term 0.88 (0.30 to 2.57) 0.809
Additive interaction (coefficient scale)
RERI −0.06 (−1.59 to 1.47) 0.935
AP −0.04 (−0.88 to 0.81) 0.935
S 0.93 (−0.68 to 2.54) 0.259

AP, attributable proportion; RERI, relative excess risk due to interaction; S, synergy index; SES, socioeconomic status.