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. 2025 Aug 4;11(8):1670–1680. doi: 10.1038/s41477-025-02056-z

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© The Author(s) 2025

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 2 — Phylogram of the relationship between A. thaliana AUX/LAX members and most solved APC structures (345 PDB codes from 50 unique protein sequences were identified in Oct 2024). AUX/LAX forms a distinct clade and share less 15% sequence identity to other structurally solved APC superfamily members.