Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2025 Jul 28;11(8):1628–1641. doi: 10.1038/s41477-025-02049-y

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2025

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Extended Data Fig. 8 — a, dN/dS of each FLS2 concave-surface residue in relation to its minimal distance to flg22. The top part are the marginal density distributions of minimal distances for residues under positive selection (dN/dS > 1, blue) versus purifying/neutral selection (dN/dS ≤ 1, gray). The bottom part presents a scatter plot of all FLS2 concave-surface residues, color-coded by whether dN/dS ≤ 1 (gray) or dN/dS > 1 and closest to flg22 (blue). b, dN/dS of each FLS2 concave-surface residue in relation to its minimal distance to SERK3. The top part are the marginal density distributions of minimal distances for residues under positive selection (dN/dS > 1, gold) versus purifying/neutral selection (dN/dS ≤ 1, gray). The bottom part presents a scatter plot of all FLS2 concave-surface residues, color-coded by whether dN/dS ≤ 1 (gray) or dN/dS > 1 and closest to flg22 (gold). Residues with a high probability (BEB probability > 0.95) of being under positive selection are shown in red. LRRs 10–20, corresponding to the flg22 C-terminus and SERK3-binding region, are outlined in black. The dashed red line at dN/dS = 1 indicates the threshold between purifying/neutral and diversifying selection. Distances are shown in Å. dN/dS for each residue was calculated as described in (Fig. 6a), then mapped onto the structural models shown in (Fig. 6f–h). Minimal atom–atom distances between each FLS2 residue and flg22/SERK3 were extracted from the same structural models.