TABLE 3.
Univariable Cox regression analysis for antibody-mediated rejection (ABMR).
| Univariable cox regression for ABMR a | HR | CI 95% INF | CI 95% SUP | p |
|---|---|---|---|---|
| Recipient age | 0.985 | 0.966 | 1.006 | 0.158 |
| Donor age | 0.982 | 0.964 | 1.001 | 0.061 |
| Deceased donor | 2.000 | 0.798 | 5.015 | 0.139 |
| DCD | 0.910 | 0.519 | 1.519 | 0.743 |
| Induction immunosuppression | 1.478 | 0.795 | 2.747 | 0.216 |
| First kidney transplant | 0.523 | 0.308 | 0.888 | 0.016 |
| Combined transplant | 0.645 | 0.201 | 2.068 | 0.461 |
| CIT | 1.022 | 0.986 | 1.059 | 0.235 |
| DGF | 1.779 | 1.026 | 3.083 | 0.040 |
| cPRA at the time of transplant | 1.009 | 1.003 | 1.016 | 0.007 |
| HLA-A mismatch >0 | 1.506 | 0.601 | 3.773 | 0.382 |
| HLA-B mismatch >0 | 1.237 | 0.448 | 3.418 | 0.682 |
| HLA-DRB1 mismatch >0 | 2.059 | 0.822 | 5.157 | 0.123 |
| HLA mismatch – sum of A, B and DRB1 mismatch | 1.069 | 0.884 | 1.293 | 0.490 |
| Early-DSA | 3.279 | 1.696 | 6.339 | <0.001 |
| Late-DSA | 3.981 | 1.882 | 8.421 | <0.001 |
ABMR: antibody-mediated rejection. DCD: donor circulatory death. CIT: cold ischemia time. DGF: delayed graft-function. cPRA: calculated panel-reactive antibody (Eurotransplant). DSA: donor-specific HLA, antibody.
a
To evaluate the predictive capacity of DSA, by Cox regression, patients with ABMR before DSA appearance were eliminated from this analysis.