TABLE 2.
Multivariable Cox regression model for long-term graft survival, pooled from 20 imputed datasets. For restricted cubic splines see Figure 4 and Supplementary Figure S1.
| Variable | Hazard ratio (95% CI) | P value |
|---|---|---|
| Donor age | 1.011 (0.996–1.026) | 0.164 |
| Donor BMI | 0.991 (0.960–1.024) | 0.607 |
| Donor cause of death | ||
| Head trauma | Ref | |
| Drug overdose | 0.860 (0.601–1.231) | 0.411 |
| Other | 0.763 (0.577–1.008) | 0.057 |
| Donor type | ||
| DBD | Ref | |
| DCD | 1.218 (0.613–2.418) | 0.573 |
| Pancreas preservation time | 0.986 (0.956–1.016) | 0.359 |
| HLA Mismatch | 0.950 (0.848–1.065) | 0.380 |
| CMV Match | ||
| P/N = Yes | Ref | |
| P/N = No | 0.812 (0.620–1.062) | 0.129 |
| Duct management | ||
| Enteric Drainage | Ref | |
| Bladder Drainage | 1.608 (0.920–2.809) | 0.095 |
| Other | 1.171 (0.688–1.995) | 0.561 |
| Steroids maintenance | ||
| Yes | Ref | |
| No | 0.966 (0.732–1.276) | 0.810 |
| Donor ethnicity | ||
| Black | Ref | |
| White | 0.996 (0.734–1.351) | 0.979 |
| Other | 0.946 (0.664–1.350) | 0.761 |
| Recipient BMI | 1.004 (0.972–1.038) | 0.809 |
| cPRA | ||
| <20 | Ref | |
| ≥20 | 1.069 (0.790–1.447) | 0.664 |
| Recipient diabetes type | ||
| Type 1 | Ref | |
| Type 2 | 1.170 (0.849–1.612) | 0.338 |
| Previous pancreas transplant recipient | ||
| No | Ref | |
| Yes | 0.706 (0.165–3.016) | 0.639 |
| Recipient on dialysis | ||
| No | Ref | |
| Yes | 1.545 (1.123–2.126) | 0.008 |
| Treated for pancreas rejection in first year | ||
| No | Ref | |
| Yes | 1.744 (1.201–2.532) | 0.003 |
| Treated for kidney rejection in first year | ||
| No | Ref | |
| Yes | 1.118 (0.736–1.697) | 0.601 |
| RCS: Recipient age | RCS terms | 0.010 |
| RCS: HbA1c at first year follow-up | RCS terms | <0.001 |
| RCS: C-Peptide at first year follow-up | RCS terms | 0.034 |
| RCS: eGFR at first year follow-up | RCS terms | <0.001 |
BMI, Body mass index; cPRA, Calculated panel reactive antibody; CMV, Cytomegalovirus; DBD, Donation after brain death; DCD, Donation after circulatory death; eGFR, Glomerular filtration rate; HbA1c, Glycosylated hemoglobin; HLA, Human leukocyte antigen; P/N, Donor positive, recipient negative; RCS, Restricted cubic splines.