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. 2025 May 24;23(5):869–883. doi: 10.1007/s40258-025-00977-6

Table 1.

Relative effect on cardiovascular events and mortality per 1 mmol/L reduction in LDL-C

Event Application in model base-case Relative risk (95% confidence interval) Source
Major cardiovascular event Non-coronary revascularisation 0.78 (0.76 to 0.80) CTT collaboration 2010 [2]
Any coronary revascularisation Elective coronary revascularisation 0.74 (0.71 to 0.79) Weighted average using CTT collaboration 2010 [2]
Ischaemic stroke Ischaemic stroke 0.78 (0.69 to 0.80) Weighted average using CTT collaboration 2010 [2]
Myocardial infarction Myocardial infarction 0.73 (0.67 to 0.80) Weighted average using CTT collaboration 2010 [2]
Coronary heart disease death CVD death (sensitivity analysis only) 0.80 (0.74 to 0.87) CTT collaboration 2010 [2]
All-cause mortality All deaths 0.90 (0.87 to 0.93) CTT collaboration 2012 [18]