Table 1.

Changes in body composition from baseline to 24 months during semaglutide treatment. BMC = bone mineral content

Body Composition	Baseline (mean ± SD) [95%CI of SD]	6 Months (𝚫 baseline) [95% CI]	12 Months (𝚫 baseline) [95% CI]	24 Months (𝚫 baseline) [95% CI]
Weight (kg)	126 ± 42 [24–156]	−20 [–26; − 14]	−25 [–45; − 6]	−21 [–32; − 9]
BMI (kg/m²)	48.0 ± 9.4 [5.3–35.1]	−7.9 [–10; − 5.5]	−9.7 [–15.5; − 3.9]	−8.0 [–11.9; − 4.0]
Fat Mass (kg	59 ± 19 [11–70]	−10 [–15; − 6]	−12 [–21; − 4]	−7 [–14; 0]
Lean Mass (kg)	67 ± 23 [13–85]	−11 [–22; 0]	−12 [–23; − 1]	−13 [–20; − 6]
Bone Mineral Content (g)	1723 ± 347 [196–1293]	45 [–21; 110]	49 [–26; 124]	1 [–97; 98]