Table 2.

Characteristics and risk of bias assessment on the studies development of the EQ-5D-Y-3L and EQ-5D-Y-5L

PROM	References	Country of development	Construct definition	Target population for that the PROM was developed	Intended context of use	Concept elicitation study		Cognitive interview study?	Overall development study quality (risk of bias)
						Quality (risk of bias)	Patients involved?
EQ-5D-Y-3L	Wille, 2010	Germany, Italy, Spain, and Sweden	“The concept of HRQoL focuses on the viewpoint of the individual and is factored into different areas of health assessment, such as the impact of disease on daily living and functioning or health care utilization”	Healthy and chronically ill children and adolescents aged 8–18 years old	“It has been utilized internationally in many settings, such as clinical trials and population surveys. Its dissemination is supported by its concise contents, its applicability to a wide range of health conditions and its twofold reporting format, both as a descriptive profile and as an index which can be interpreted as a preference value. Although the literature emphasizes the use of EQ-5D in economic evaluations, it can nevertheless also be used as a measure of health status in general (non-economic) health assessments.”	Doubtful	Yes	Yes	Doubtful
EQ-5D-Y-5L	Kreimeier, 2019	Germany, Spain, Sweden, and United Kingdom	Not reported; assumed same of EQ-5D-Y-3L	Healthy and chronically ill children and adolescents aged 8–15 years old	Not reported; we assumed same of EQ-5D-Y-3L	Doubtful	Yes	Yes	Doubtful

COSMIN risk of bias: very good, adequate, doubtful, or inadequate quality. Development studies of the EQ-5D-3L and EQ-5D-5L (adult versions) instruments are not presented in this table because they were already assessed in another review

PROM patient-reported outcome measure, HRQoL health-related quality of life