Table 4.
Certainty of evidence for the measurement properties of each child EQ-5D version
| PROM | EQ-5D-Y-3L Self-reported version |
EQ-5D-Y-3L Proxy-reported version |
EQ-5D-Y-5L Self-reported version |
EQ-5D-Y-5L Proxy-reported version |
||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Overall rating | Certainty of evidence | Articles (n) | Overall rating | Certainty of evidence | Articles (n) | Overall rating | Certainty of evidence | Articles (n) | Overall rating | Certainty of evidence | Articles (n) | |
| +/−/? | high, moderate, low, very low | +/−/? | high, moderate, low, very low | +/−/? | high, moderate, low, very low | +/−/? | high, moderate, low, very low | |||||
| Descriptive system | ||||||||||||
| Content validity | ||||||||||||
| Relevance | ± | Very lowʀʀ± | 1 (103) | + | Lowʀʀ | 1 (120) | ||||||
| Comprehensiveness | + | Moderateʀ | 1 (103) | + | Moderateʀ | 1 (120) | ||||||
| Comprehensibility | + | Moderateʀ | 1 (103) | + | Moderateʀ | 1 (120) | ||||||
| Reliability | − | Moderateʀ | 13 (2738)b,c | − | Moderateʀ | 8 (1484)b | − | Lowʀ± | 7 (512)b,c | − | Low±± | 5 (252) |
| Criterion validity | − | Very lowʀʀʀ | 1 (118) | |||||||||
| Construct validity | − | Moderateʀ | 26 (16490)a,b,c | − | Lowʀʀ | 5 (1666)b | ± | Not rated |
10 (8380)d |
− | Moderateʀ | 2 (520) |
| Responsiveness | − | Very lowʀʀʀ≠ | 1 (83) | |||||||||
| EQ VAS | ||||||||||||
| Reliability | + | Moderateʀ | 9 (2512)b,c | − | Lowʀʀ | 5 (1309)b | − | Very lowʀ±± | 2 (945)b,c | − | Very lowʀ±± | 3 (339) |
| Criterion validity | − | Very lowʀʀʀ | 1 (118) | |||||||||
| Construct validity | − | Moderateʀ | 12 (5258)b,c | − | Lowʀʀ | 3 (1106)b | − | Moderateʀ | 5 (996)b | − | Very lowʀʀʀ | 1 (234) |
| Responsiveness | + | Lowʀʀ |
4 (361)b |
+ | Very lowʀ≠≠ | 1 (30) | + | Very lowʀ≠≠ | 1 (42) | |||
| Utility score | ||||||||||||
| Reliability | + | Moderateʀ |
4 (251) |
− | Lowʀ± | 2 (310)b | ||||||
| Construct validity | − | Low±± |
10 (3090)b |
− | Lowʀʀ | 1 (321)b | − | Lowʀʀ | 1 (298) | |||
| Responsiveness | + | Moderateʀ |
6 (571)b |
+ | Moderateʀ | 2 (128) | − | Very lowʀʀʀ | 1 (110) | |||
Overall ratings: ‘+’ = sufficient; ‘−’ = insufficient; ‘?’ = indeterminate; ‘±’ = inconsistent. Certainty of evidence: high, moderate, low, very low. Reasons of downgrade: ‘ʀ’ downgrade due to the risk of bias; ‘±’ downgrade due to inconsistency; ‘¥’ downgrade due to the indirectness; ‘≠’ downgrade due to the imprecision. We carefully sum the participants who underwent a test and retest according to the studies’ description. We considered as criterion validity when studies correlated the EQ-5D instruments with a recognized disease-specific gold standard
PROM patient-reported outcome measure, n number of participants considered for each measurement property
aWe considered the smallest number in the sum of the total sample by measurement property when a study had a variation in the number of participants
bWhen an article presented two or more studies (subsamples) on a measurement property
cWe did not consider the same sample twice in the sum of the total sample by measurement property when a study had overlapping samples (same sample in different articles)
dWe considered as inconsistent because half of the studies were rated as sufficient and the other one as insufficient with unexplained reasons