Table 3.
Top 25 Reactome pathways from the enrichment analysis of genomic data.
| Pathway ID | Category | Pathway name | Entities | Reactions | Overlapped gene | ||||
|---|---|---|---|---|---|---|---|---|---|
| Found/Total | Ratio | p value | FDR | Found/Total | Ratio | ||||
| R-HSA-451308 | Calcium and sodium | Activation of Ca-permeable kainate receptor | 2/13 | 8.96E-04 | 1.51E-04 | 0.007339 | 2/2 | 1.57E-04 | GRIK2 |
| R-HSA-451306 | Calcium and sodium | Ionotropic activity of kainate receptors | 2/14 | 9.65E-04 | 1.75E-04 | 0.007339 | 4/4 | 3.15E-04 | GRIK2 |
| R-HSA-451326 | Calcium and sodium | Activation of kainate receptors upon glutamate binding | 2/34 | 0.002343 | 0.001014 | 0.023828 | 4/6 | 4.72E-04 | GRIK2 |
| R-HSA-9008059 | Interleukin | Interleukin-37 signaling | 2/36 | 0.00248 | 0.001135 | 0.023828 | 1/14 | 0.001102 | PTPN5 |
| R-HSA-112314 | Neurotransmitter | Neurotransmitter receptors and postsynaptic signal transmission | 3/232 | 0.015985 | 0.003798 | 0.060767 | 9/109 | 0.008583 | GRIK2; ADCY7 |
| R-HSA-451307 | Calcium and sodium | Activation of Na-permeable kainate receptors | 1/5 | 3.44E-04 | 0.006867 | 0.094675 | 2/2 | 1.57E-04 | GRIK2 |
| R-HSA-112315 | Neurotransmitter | Transmission across chemical synapses | 3/352 | 0.024252 | 0.01194 | 0.094675 | 9/161 | 0.012677 | GRIK2; ADCY7 |
| R-HSA-446652 | Interleukin | Interleukin-1 family signaling | 2/163 | 0.011231 | 0.020955 | 0.094675 | 1/79 | 0.00622 | PTPN5 |
| R-HSA-170660 | PKA activation and energy transform | Adenylate cyclase activating pathway | 1/17 | 0.001171 | 0.023167 | 0.094675 | 4/4 | 3.15E-04 | ADCY7 |
| R-HSA-170670 | PKA activation and energy transform | Adenylate cyclase inhibitory pathway | 1/18 | 0.00124 | 0.024514 | 0.094675 | 5/5 | 3.94E-04 | ADCY7 |
| R-HSA-177504 | Neurotransmitter | Retrograde neurotrophin signaling | 1/18 | 0.00124 | 0.024514 | 0.094675 | 2/3 | 2.36E-04 | SH3GL2 |
| R-HSA-8875360 | InlB-mediated entry of Listeria monocytogenes into host cell | 1/19 | 0.001309 | 0.025859 | 0.094675 | 2/8 | 6.30E-04 | SH3GL2 | |
| R-HSA-112316 | Neurotransmitter | Neuronal system | 3/498 | 0.034312 | 0.029756 | 0.094675 | 9/214 | 0.01685 | GRIK2; ADCY7 |
| R-HSA-164378 | PKA activation and energy transform | PKA activation in glucagon signaling | 1/23 | 0.001585 | 0.031221 | 0.094675 | 1/2 | 1.57E-04 | ADCY7 |
| R-HSA-163615 | PKA activation and energy transform | PKA activation | 1/23 | 0.001585 | 0.031221 | 0.094675 | 1/4 | 3.15E-04 | ADCY7 |
| R-HSA-6807004 | PKA activation and energy transform | Negative regulation of MET activity | 1/25 | 0.001722 | 0.033892 | 0.094675 | 2/10 | 7.87E-04 | SH3GL2 |
| R-HSA-111931 | PKA activation and energy transform | PKA-mediated phosphorylation of CREB | 1/26 | 0.001791 | 0.035224 | 0.094675 | 1/7 | 5.51E-04 | ADCY7 |
| R-HSA-8876384 | Others | Listeria monocytogenes entry into host cells | 1/27 | 0.00186 | 0.036555 | 0.094675 | 2/13 | 0.001024 | SH3GL2 |
| R-HSA-182971 | Cell growth | EGFR downregulation | 1/37 | 0.002549 | 0.049769 | 0.094675 | 9/22 | 0.001732 | SH3GL2 |
| R-HSA-163359 | PKA activation and energy transform | Glucagon signaling in metabolic regulation | 1/40 | 0.002756 | 0.0537 | 0.094675 | 2/6 | 4.72E-04 | ADCY7 |
| R-HSA-432720 | Cell growth | Lysosome vesicle biogenesis | 1/43 | 0.002963 | 0.057615 | 0.094675 | 2/8 | 6.30E-04 | SH3GL2 |
| R-HSA-111933 | Calcium and sodium | Calmodulin induced events | 1/43 | 0.002963 | 0.057615 | 0.094675 | 1/23 | 0.001811 | ADCY7 |
| R-HSA-111997 | Calcium and sodium | CaM pathway | 1/43 | 0.002963 | 0.057615 | 0.094675 | 1/24 | 0.00189 | ADCY7 |
| R-HSA-379726 | Mitochondria | Mitochondrial tRNA aminoacylation | 1/47 | 0.003238 | 0.062811 | 0.094675 | 1/21 | 0.001654 | CARS2 |
| R-HSA-111996 | Calcium and sodium | Ca-dependent events | 1/48 | 0.003307 | 0.064106 | 0.094675 | 1/27 | 0.002126 | ADCY7 |