Figure 1.

Mutants isolated from a screen for suppressors of ced-9(n1950). (A) Approximately 50-cell stage embryo carrying the n3196 mutation, which confers a maternal-effect lethal phenotype characterized by vacuolization (arrows) and degeneration of the embryo. (B) Two-fold stage embryo carrying the n3213 mutation, which confers a phenotype similar to that of n3196 embryos but is restricted to the posterior portion (bracket) of the embryo. The abnormality first appears in approximately comma-staged embryos. (C) Comma-stage cup-5(n3194) embryo derived from a homozygous cup-5(n3194) mother showing early appearance of refractile bodies (arrows). (D) cup-5(n3194) embryo arrested at approximately the two-fold stage filled with refractile bodies.